Table 1. Summary of Genes Regulated by MYC MYC-ER1: MYC-ER2: MYC-ER3: Cycloheximide: HL60: Accession MYC-ER + OHT/ MYC-ER + OHT/ MYC-ER + OHT/ MYC-ER + OHT + cx/ 0 hours/ Number control + OHT control + OHT control + OHT cont + OHT + cx 24 hours Induced Genes Ornithine decarboxylase 1 X55362 5.0 5.2 7.5 2.5 3.1 AHCY S-adenosylhomocysteine hydrolase M61832 2.3 2.4 7.3 6.8 3.4 CCND2 Cyclin D2 D13639 4.8 2.2 5.7 4.4 5.6 ASS Argininosuccinate synthetase T51288 2.7 2.1 5.5 2.9 0.5 "FKBP52, 52 kDa FK506 binding protein" T70920 14.7 4.3 5.4 2.4 4.2 Pre-B cell enhancing factor (PBEF) U02020 2.5 4.0 5.2 1.9 0.4 Tumor necrosis factor receptor associated protein (TRAP1) R61502 4.3 4.5 5.0 2.8 2.9 "FABP5, Psoriasis-associated fatty acid binding protein" H73758 8.3 13.6 4.7 2.7 10.0 Nucleolin H17434 2.4 2.7 4.5 4.0 2.2 "GOS2, lymphocyte G0/G1 switch gene 2" M69199 7.3 4.0 4.4 6.1 1.0 PPIF (hCyp3) Mitochondrial cyclophilin H55916 3.8 3.9 4.3 3.6 0.7 RNA polymerase II subunit (hsRPB8) Z49199 2.8 2.4 4.0 1.4 1.3 Fibrillarin T57468 3.9 4.4 3.9 3.5 2.0 "TFRC Transferrin receptor (p90, CD71)" R23889 2.3 2.4 3.9 2.4 9.1 CksHs2 X54942 2.4 2.1 3.3 3.7 3.2 SLC16A1 Solute carrier family 16 L31801 11.1 2.7 2.9 2.0 5.6 IARS Isoleucine-tRNA synthetase U04953 5.9 2.1 2.9 2.6 1.3 "HLA-DRB1 Major histocompatibility complex, DR beta 5" T62633 3.4 8.9 2.9 0.4 0.5 EST highly similar to GRPE protein homolog precursor T51856 9.7 3.1 2.8 2.0 7.1 GPI Glucose phosphate isomerase R49964 3.1 2.5 2.7 1.6 0.5 HSPD1 Heat shock 60 kD protein 1 (chaperonin) M22382 2.7 2.3 2.7 1.8 2.2 Hepatoma-derived growth factor D16431 2.2 2.3 2.6 2.6 2.5 Splicing factor SF2 R60749 4.3 3.6 2.5 1.6 6.3 Coup transcription factor M37197 3.2 2.9 2.5 1.1 2.4 RPS11 Ribosomal protein S11 X60673 7.3 2.6 2.4 1.6 1.3 EIF5A Eukaryotic translation initiation factor 5A M23419 3.0 2.3 2.3 2.3 4.8 EIF4G Eukaryotic translation initiation factor 4 gamma R39681 2.4 3.8 2.1 0.7 1.1 Repressed Genes p311 (neuronal protein 3.1) U30521 0.29 0.38 0.15 0.13 0.43 A2M Alpha-2-macroglobulin T69425 0.10 0.22 0.18 0.22 0.22 TPM1 Tropomyosin alpha chain (skeletal muscle) Z24727 0.33 0.31 0.20 0.14 1.10 "PDGFRA Platelet derived growth factor receptor, alpha" H23235 0.43 0.30 0.30 0.42 1.00 FN1 Fibronectin 1 M76378 0.48 0.39 0.30 0.35 0.53 CTGF Connective tissue growth factor X78947 0.32 0.33 0.31 0.24 1.00 COL3A1 Alpha-1 type 3 collagen X06700 0.34 0.38 0.39 0.33 1.00 "CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1)" U03106 0.24 0.48 0.41 0.33 0.04 EST moderately similar to dithiolethione-inducible gene-2 R73450 0.22 0.38 0.44 0.93 0.28 Genes are listed in order of fold induction in experiment 3 "The following genes were not present on the microarrays: EIF2a, CAD, ECA-39, MrDb, telomerase, LAF-1a, HLA-A2, gadd45, C/EBPa, iron regulatory protein 2" 3.448275862 2.631578947 6.666666667 7.692307692 2.325581395 10.20408163 4.545454545 5.555555556 4.545454545 4.545454545 3.03030303 3.225806452 5 7.142857143 0.909090909 2.325581395 3.333333333 3.333333333 2.380952381 1 2.083333333 2.564102564 3.333333333 2.857142857 1.886792453 3.125 3.03030303 3.225806452 4.166666667 1 2.941176471 2.631578947 2.564102564 3.03030303 1 4.166666667 2.083333333 2.43902439 3.03030303 23.80952381 4.545454545 2.631578947 2.272727273 1.075268817 3.571428571