Previously Reported Myc Targets							
							
Protein	Myc Binding Site	Position	Criteria	Function	Myc-Estrogen Receptor	Myc-Estrogen Receptor with Cycloheximide 	References
Induced Genes					MYC-ER + OHT / control + OHT	MycER + 4OHT +cx /                     control +4OHT + cx	
Ornithine decarboxylase	gcCACGTGFtc(30)caCACGTGgc	Intron 1	"MYC-ER, CHX, mediator of apoptosis"	Polyamine biosynthesis	"5.0, 5.1, 7.5"	2.5	Bello-Fernandez et al. 1993; Wagner et al. 1993
cdc25A	gcCATGTGca()gaCATGTGct   gaCACGTGcc	Intron 1             Intron2	"MYC-ER, CHX, mediator of apoptosis, transforming ability"	Activator of cyclin-dependent kinases	"2.5, Absent, Absent"	Absent	Galaktionov et al. 1996
p53	ccCACGTGct	Exon 1	Myc activates p53 promoter	Tumor suppressor	"1.1, 2.6, 2.0"	1.2	Reisman et al. 1993
a-prothymosin	agCACGTGgc	Intron 1	"MYC-ER, CHX"	Chromatin remodelling	"0.9, 1.3, 1.3"	0.9	Eilers et al. 1991
Lactate dehydrogenase			"Overexpressed with myc in Rat1A, mediates apoptosis, transforming ability"	Anaerobic glycolysis	"1.6, 1.1, 2.1"	2.5	Shim et al. 1997; Shim et al. 1998
Heat shock  70 kDa protein			Myc activates hsp70 promoter	Stress response	"1.5, 1.6, 2.6"	2.5	Kingston et al. 1984
Eurkaryotic Initiation Factor 4E			"Expression after stimulation, MYC-ER, myc-transformed rat embryo fibroblasts"	Protein synthesis	"Absent, Absent, Absent"	Absent	"Rosenwald et al., 1983"
Repressed Genes							
Thrombospondin-1			Myc-glucocorticoid receptor	PDGF-regulated secreted glycoprotein	"0.27, 0.42, 0.57"	0.26	Tikhonenko et al. 1996
Albumin			Myc represses albumin promoter	Carrier for molecules in blood	"1.3, 2.2, 1.0"	2.2	Li et al. 1994
Ferritin Heavy Chain			Myc overexpressing EBV immortalized B cells	Iron metabolism	"2.1, 1.0, 1.9"	1.6	Wu et al. 1999
							
"The following genes were not present on the microarrays: EIF2a, CAD, ECA-39, MrDb, telomerase, LAF-1a, HLA-A2, gadd45, C/EBPa, iron regulatory protein 2"							
							
"""Absent"" indicates no confidence that the desired transcript was measured accurately, either because the transcript was rare or because of potential for cross-hybridization"